Nature (Nature) | Latest Research

Abstract The Matteson homologation, first developed in 1980, elongates carbon chains by insertion into a C−B bond.1 This versatile reaction traditionally requires three steps: carbanion formation, nucleophilic addition to organoboron, and a thermo- or Lewis acid-promoted boronate rearrangement. The

A young progenitor for the most common planetary systems in the Galaxy

Abstract The Galaxy’s most common known planetary systems have several Earth-to-Neptune-size planets in compact orbits1. At small orbital separations, larger planets are less common than their smaller counterparts by an order of magnitude. The young star V1298 Tau hosts one such compact planetary s

A hidden diversity of ceratopsian dinosaurs in Late Cretaceous Europe

Abstract Late Cretaceous Europe was an archipelago with a dinosaur fauna characterized by island effects such as low diversity, relictualism and insular dwarfism1. Its dinosaur communities include a unique mix of groups with typical Laurasian or Gondwanan affinities and distinctive endemics1. Chief

Surface optimization governs the local design of physical networks

Abstract The brain’s connectome1,2,3 and the vascular system4 are examples of physical networks whose tangible nature influences their structure, layout and, ultimately, their function. The material resources required to build and maintain these networks have inspired decades of research into wirin

Prefrontal neural geometry of learned cues guides motivated behaviours

Abstract Animals continuously evaluate their surroundings to decide whether to approach rewarding opportunities or avoid potential threats. Assigning the appropriate importance to environmental stimuli is not only crucial for survival but also underlies complex forms of goal-directed behaviour that

High-voltage anode-free sodium–sulfur batteries

Abstract Room-temperature sodium–sulfur (Na–S) batteries offer a sustainable energy storage solution to conventional lithium (Li)-based systems1,2,3, owing to the high element abundances and theoretical electrochemical performance4,5. However, their practical applications have been severely hindere

Plastic landmark anchoring in zebrafish compass neurons

Abstract Vision can inform animals as they navigate their environment. Landmarks can be used to maintain heading, while optic flow can be integrated to estimate turning. Although it has been shown that head direction (HD) neurons in various species use these visual cues1,2, the circuit mechanisms u

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity

Abstract In all domains of life, tRNAs mediate the transfer of genetic information from mRNAs to proteins. As their depletion suppresses translation and, consequently, viral replication, tRNAs represent long-standing and increasingly recognized targets of innate immunity1,2,3,4,5. Here we report Ca

An expanded registry of candidate cis-regulatory elements

Abstract Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression1. Previously, the ENCODE consortium mapped biochemical signals across hundreds of cell types and tissues and integrated these data to develop a registry containing 0.9 million hum

Soft biodegradable implants for long-distance and wide-angle sensing

Abstract Monitoring internal physiological signals is essential for effective medical care1, yet most current technologies rely on external measurements or imaging systems that cannot capture enough deep-tissue dynamics2,3,4,5,6. Implantable devices offer a solution, but conventional designs often

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit

Abstract The stromal cell compartment plays a central part in the maintenance of tissue homeostasis by coordinating with the immune system throughout inception, amplification and resolution of inflammation1. Chronic inflammation can impede the phased regulation of tissue restitution, resulting in t

Pulse heating and slip enhance charging of phase-change thermal batteries

Abstract Phase-change thermal batteries for renewable energy storage and waste heat recovery demand high energy density and fast charging1,2,3,4,5, which are mutually exclusive because phase-change materials (PCMs) with high melting enthalpy are usually poor heat conductors6,7,8. The charging rate

Systematic analyses of lipid mobilization by human lipid transfer proteins

Abstract Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and auxiliary lipids facilitating transfer remain unknown. We have combined biochemical, lipidomic and co

Climate change shifts the North Pacific storm track polewards

Abstract Across the North Pacific Ocean, the mid-latitude storm track accounts for most of the heat and moisture transport into the Arctic and western North America, considerably influencing regional precipitation and temperature patterns1,2. By the end of this century, the winter North Pacific sto

Genetic switch between unicellularity and multicellularity in marine yeasts

Abstract The evolution of multicellularity is considered to be a major transition in the history of life on Earth1. In the evolution from unicellularity to obligate multicellularity, facultative clonal multicellularity may constitute an intermediate state, in which unicellular proliferation and clo

Nutrient requirements of organ-specific metastasis in breast cancer

Abstract Cancer metastasis is a major contributor to patient morbidity and mortality1, yet the factors that determine the organs where cancers can metastasize are incompletely understood. Here we quantify the absolute levels of 124 metabolites in multiple tissues in mice and investigate how this re

Neuro-epithelial circuits promote sensory convergence and intestinal immunity

Abstract Type 2 inflammation at barrier surfaces is an evolutionarily conserved response that promotes immunity to helminth parasites, allergic inflammation and tissue repair1,2,3,4. Direct sensing of environmental triggers by epithelial cells initiates type 2 inflammation, and signals derived from

Insights into DNA repeat expansions among 900,000 biobank participants

Abstract Expansions and contractions of tandem DNA repeats generate genetic variation in human populations and in human tissues. Some expanded repeats cause inherited disorders and some are also somatically unstable1,2. Here we analysed DNA sequencing data from over 900,000 participants in the UK B

Towards fibre-like loss for photonic integration from violet to near-infrared

Abstract Over the past decades, remarkable progress has been made in reducing the loss of photonic integrated circuits (PICs) within the telecom band1,2,3,4, facilitating on-chip applications spanning low-noise optical5 and microwave synthesis6, to lidar7 and photonic artificial intelligence engine

Early hominins from Morocco basal to the Homo sapiens lineage